The ripple effect of Neurexan® addresses stress, anxiety and disturbed sleep patterns in one over-the-counter natural product.

(Backed by clinical trials)

Efficient, natural help for your daily challenges

Neurexan®is a natural medication that allows you to manage daily challenges in a relaxed way. It provides relief from various forms of restlessness, nervousness, anxiety and related sleep disorders such as insomnia. So, you can feel calm and relaxed during the day, which will improve your sleep quality during the night.

The vicious circle..

Life is full of opportunities – but also challenges. Time is precious. So, you try to fit as much in your day as possible. Maybe it's career and family life, fitness and hobbies, or social life with friends and other relationships and commitments. Sometimes, they can just become too demanding because you commit to so many things. It's hard to juggle it all, and so it starts to weigh you down. You feel overloaded and stressed, which in return is simply exhausting – physically as well as mentally. After such a packed day, all you want is a night of good sleep. Due to the tension in your system, you may have difficulties falling asleep, or might wake up at night and can’t go back to sleep. Without a good night's sleep, the following day is often an uphill struggle, leading to even more tension and stress. The result is a vicious circle – fortunately, there are ways for you to find your inner balance again.

Turn things around with Neurexan®

Neurexan®effectively and naturally helps you regain your inner balance by lowering your stress level and decreasing nervous restlessness and related sleep disorders. Break your vicious circle by going calmly through the day, feeling relaxed, and therefore sleeping better at night.

Enjoy a relaxed day so you can sleep

better at night....


For an active day

Your nervous system reacts to stressful times by releasing stress hormones such as cortisol to cope with the situation better. However, if your daily life's challenges give you no time to recuperate, then your nervous system triggers an ongoing stress response. A continuous strain can lead to symptoms such as nervous restlessness, headache, chest pain and many more. Neurexan® offers natural help for you to cope with daily challenges. During the day, you regain your inner balance and can handle stressful situations more calmly. Concentration and performance are retained without any risk of addiction or drowsiness.


For a restful night

Nervous restlessness isn't just a daytime symptom. It even continues into the night, and related sleep disorders are the result. Your body needs sleep to recover from the strains it experienced during the day. But getting a good night's sleep is easier said than done, especially when you're restless. Even a few sleepless nights can lead to symptoms such as restlessness, insomnia, fatigue, and many more. Neurexan® helps you to calm down and to rest your mind. The stress hormone cortisol plays a vital role in stress and sleep. If you take Neurexan® three times a day, it will contribute to decreasing cortisol levels , helping you relax during the day so you can sleep better at night.

Find your way to calm....

Scientific evidence for positive effects of Neurexan®

Several scientific studies have shown that Neurexan® has the following benefits:


Studies have confirmed the effectiveness of Neurexan® in alleviating symptoms of nervousness, restlessness, daytime fatigue, and insomnia.


Neurexan® reduces the stress reaction in stress-relevant brain regions of the central nervous system. The stress hormone cortisol plays a vital role in stress and sleep. The intake of Neurexan® reduces the increase of cortisol levels and thus helps you to relax.

Well Tolerated

With Neurexan®, you can be fit and active during the day without worrying about drowsiness or addiction. 90%-91% of patients reported “good” or “excellent” tolerability. It can be used for short-term as well as for long-term treatments at acute or chronic conditions. Neurexan® does not interact with other medications.

A Natural Combination....

Neurexan®’s four ingredients are derived naturally so you can be sure it contains only plant and mineral components. The unique combination of these natural components is key to Neurexan®’s effects:


The Passiflora plant has been traditionally used over the centuries for several health purposes. Passionflower is particularly effective in treating, e.g. nervousness, anxiety and sleep difficulties.


Oat is known as a „superfood“ for its many health benefits, such as lowering cholesterol levels and treating exhaustion and sleep issues.

Coffee Plant

The caffeine in coffee is not only known to improve moods. It also increases serotonin levels in the brain, which reduces depressive tendencies and relaxes us, and therefore helps against insomnia.

Valerian Zinc Salt

The zinc salt contains valerian, which helps against nervousness and sleep disturbances without causing drowsiness.

Still have your doubts about Neurexan®?


"I don’t believe natural medication really helps.“

When it comes to natural medication, some people have reservations that it works. But you can be sure that Neurexan®has a positive effect, starting within the first hour after intake. Several scientific studies have confirmed its effectiveness in alleviating symptoms such as nervousness, restlessness, daytime fatigue, and insomnia. The natural ingredients Passionflower, Oat, Valerian Zinc Salt, and Coffee Plant all work within the central nervous system, where key signaling processes occur when stress and tension rise.


"I‘m afraid of an addiction.“

We understand that this can always be a concern – and we are taking this topic very seriously, too. That's why we can assure you: Neurexan®'s natural ingredients – Passionflower, Oat, Valerian Zinc Salt, and Coffee Plant – aren't habit-forming, so there is no risk of addiction when taking it. You can safely stop taking Neurexan®when you feel you don't need it and go back to taking it when your daily challenges again become more demanding.


"Why should I take medicine? I don’t have a problem.“

We know that mastering the daily challenges can be difficult. But this is just a part of life. And everyone goes through at some point in time. Your symptoms may not yet be severe, but you should be aware that there is a possibility that they can get worse. Having this in mind, it is important to know that the sooner you take action, the sooner you will be able to break or not even enter the vicious circle of tension, anxiety, daytime fatigue and related sleep disorders. Neurexan®can help you on your way to return to life at its fullest – with its unique combination of benefits for both day and night. During the day, Neurexan®helps you to regain your inner balance and deal calmly with stressful situations, nervous restlessness, tension and strains, which leads to better sleep at night. This unique combination of benefits for both day and night supports you effectively in turning things around.

Want to know more about Neurexan®?

Is there any scientific evidence?

  1. Doering BK, et al. Life Sci. 2016;146:139-147.
  2. Waldschütz R, Klein P. ScientificWorldJournal. 2008;8:411-420.https://doi.org/10.1100/tsw.2008.61
  3. Hübner R, et al. ScientificWorldJournal. 2009;9:733-745
  4. Herrmann, L., Vicheva, P., Kasties, V. et al. fMRI Revealed Reduced Amygdala Activation after Nx4 in Mildly to Moderately Stressed Healthy Volunteers in a Randomized, Placebo-Controlled, Cross-Over Trial. Sci Rep 10, 3802 (2020).
  5. Dimpfel W. WJNS. 2019;09(03):100-112.
  6. Mayer K, Krylova M, Alizadeh S, Jamalabadi H, van der Meer J, Vester JC, Naschold B, Schultz M and Walter M (2021) Nx4 Reduced Susceptibility to Distraction in an Attention Modulation Task. Front. Psychiatry 2021;12:746215. doi: 10.3389/fpsyt.2021.746215
  7. Chand T, Alizadeh S, Jamalabadi H, Herrmann L, et al. (2021). EEG revealed improved vigilance regulation after stress exposure under Nx4 – A randomized, placebo-controlled, double-blind, cross-over trial. IBRO Neurosci Rep. 2021;11:175-182

When should I take Neurexan®?

If you are suffering from acute or constant nervous restlessness and related sleep disorders, the following dosage is recommended:
Allow one to two tablet to dissolve under the tongue up to 6 times a day.

If you are experiencing initial or occasional nervous restlessness and related sleep disorders, the following dosage is recommended:
Allow one to two tablet to dissolve under the tongue 3 times a day.

Can I take Neurexan® in parallel with other medications?

Neurexan®is well tolerated and contains naturally derived ingredients. Therefore, you can take it together with other medications. If in doubt, it is advisable to check with your pharmacist.

Are there any contraindications known for Neurexan®? If yes, which ones?

Neurexan®tablets contain lactose, so if you are lactose intolerant, you should use the drops instead of the tablets. Be advised that the drops / liquid Neurexan®contains alcohol. Also when you are allergic to any of the ingredients Neurexan® should not be taken. Otherwise, there are no serious known side effects for Neurexan®.

How can one single product keep me active during the day but at the same time help me to sleep?

Neurexan®’s special combination of natural ingredients combines benefits for both day and night: it helps you to stay in balance during the day, which means you are more relaxed. This calming effect makes it easier for you to fall asleep and leads to a better sleep at night.

How long do I need to wait until Neurexan® starts to work?

Neurexan®works swiftly after letting the tablet dissolve in your mouth – this varies a bit between people. Still, the calming effect should start to kick in within the first hour after intake.